The MTHFR Tutorial – genetic mutation and cause of miscarriage

Its not as bleak as it seems...

Its not as bleak as it seems…

Hi to all fellow Fertile Myrtle Wannabe’s
I found this post on www.FertileThoughts.com  forum where Charity kindly put together this information on the MTHFR Gene Issue.  It is certainly pertinent to my journey not only from the point of view of my infertility issues but also because I am a migraineur.  It might be pertinent to your journey, so have a read.   This is particularly interesting if you have miscarried, and are not sure of the cause.
in the interests of babymaking,
Coach Louise
MTHFR Tutorial

I’ve recently been diagnosed with having the homozygous C677T MTHFR mutation and have found various information on the subject. I was hoping this might help others that are looking for the majority of the information available in one reading…I needed to put together something to send out to my family to ensure they all got tested, so thought I’d share here. I have borrowed much of this from others, so if some sounds familiar, you likely have read it either here or on other forums. Best wishes to those who have recently been diagnosed. For those who have experienced losses, I hope your recent diagnosis and treatment proves to be the answer to your prayers. I am hopeful it’s the answer to mine and dh’s. All my best!

MTHFR Gene Mutation

What is it?
The gene MTHFR (Methylenetetrahydofolate Reductase) encodes the protein MTHFR. Its job is to convert one form of folate (5,10-Methylenetetrahydofolate) to another form of folate (5-Methyltetrahydrofolate). 5-Methyltetrahydrofolate is used to convert Homocysteine (a “bad” amino acid) to Methionine (a “good” amino acid). Therefore, if MTHFR is not doing its job as well, homocysteine will not be converted to Methionine and will be elevated in plasma. Elevated Homocysteine has been associated with a variety of multi-factorial diseases.

Essentially what this means is that the genes that instruct MTHFR to convert homocysteine to Methionine are mutated and may not be capable of doing this important function. MTHFR is an enzyme that converts Homocysteine to an essential amino acid (Methionine). When the genes are mutated you may be lacking this enzyme. Your Homocysteine levels can possibly climb making the blood clot. Some doctors don’t check for the MTHFR mutations and rely only on homocysteine levels. This isn’t as reliable as testing for the mutations, because Homocysteine levels fluctuate (if you catch your level on a normal day, you may go undiagnosed).

What Type Do I Have?
With MTHFR, there are two different genes identified for this mutation, and it’s possible to be “heterozygous,” “compound heterozygous,” or “homozygous.” The MTHFR gene mutation has varying degrees of possible implications. The order of potential severity from most to least is:
1. C677T & C677T (Two C Copies – C677T Homozygous)
2. C677T & A1298C (One Copy of Each The C & A – Compound Heterozygous)
3. C677T (One C Copy – C677T Heterozygous)
4. A1298C & A1298C (Two A Copies – A1298C Homozygous)
5. A1298C (One A Copy – A1298C Heterozygous)

The MTHFR mutation is fairly common in the general population. Approximately 44% of the population is heterozygous and another approximate 12% are homozygous for the MTHFR mutation. Compound heterozygous and homozygous MTHFR have the highest incidences of being linked to implantation failure, late term miscarriages, specific birth defects and overall vascular health. Whichever type of MTHFR you have, it should not be discounted, particularly if there is a personal or family history of any such incidences.

What Are the Implications?
Any and all of the mutations can affect homocysteine levels, but there is much dispute as to whether elevated homocysteine levels are actually needed in order for MTHFR to cause medical complications. Many other MTHFR patients have normal homocysteine levels; yet have had implantation problems, m/c(s), and/or stillbirth(s) due to clotting problems. So it is important to find out your Homocysteine levels (although again, normal doesn’t necessarily mean all is well). This is a serious field and MTHFR is a serious condition, so consulting an expert is wise.

Research shows that high homocysteine levels and/or those with the mutation show a higher propensity for thrombosis (blood clots), arteriosclerosis (hardening of arteries), Alzheimer’s, stroke, heart attack, Fibromyalgia, migraines (especially with “Aura” migraines), osteoporotic fractures, bone marrow disorders and for those of child bearing years, it has found to be connected to higher incidences of down’s syndrome, spina bifida, other neural tube defects, trisomy, miscarriage, stillbirth, implantation failure, placental abruption, preeclampsia, higher incidences of autism, amongst others. Additionally, if you test positive you may want to have your parents, siblings, and any children you may already have tested, as well. There are a few positives to this disorder. Because folate is necessary for cellular division, there is support that shows having this disorder can actually help keep certain types of cancer cells from multiplying as rapidly, so there are some benefits from having this mutation.

Treatment?
Many doctors prescribe Folgard, which is a prescription vitamin supplement containing high levels of folic acid, B12 and B6. These vitamins are what the body essentially needs to convert Homocysteine to Methionine. To put this into perspective, the average multivitamin contains 400 mcgs , most prenatals have 800mcgs of Folic Acid (200% of the normal daily value). Those that are compound heterozygous and those that are homozygous for the mutation are recommended taking 5 mgs. of Folic Acid/B vitamins (12 times the average multi-vitamin and 6 times more than prenatals). It is also recommended to begin taking a low dose (LD) aspirin (81 mgs) once a day, every day, for the rest of your life.

For those undergoing fertility treatments, often times the treatment includes Lovenox (low molecular weight heparin) or Heparin (both are anti-coagulants) during the cycle. If you have a history of implantation failure or early miscarriage, it is becoming more acceptable to use the protocol established by the well-respected Reproductive Immunologist Dr. Beers by beginning Lovenox (40mg/once a day) on cycle day 6 and continuing throughout the cycle. If pregnancy is confirmed, this dosage is likely increased (Typically up to 40mg/twice a day, but potentially higher doses are prescribed dependent upon blood work results since homocysteine levels tend to increase with pregnancy) and usage continues throughout your pregnancy. Approximately two to four weeks prior to birth, the patient is converted to Heparin and continues to take an anti-coagulant for another 6 weeks postpartum (typically switched back to Lovenox). During that time, you will typically be directed to take additional Calcium and Vitamin D, as anti-coagulants can cause bone loss (Heparin more so than Lovenox). Some doctors will recommend a bone scan after use is discontinued to ensure there are no bone density issues. While being treated with an anti-coagulant, you will typically be asked to discontinue taking the 81 mg. baby aspirin since the anti-coagulants will replace the need for the thinning property of the LD aspirin. The FDA has placed Lovenox in the pregnancy category B. Lovenox is not expected to be harmful to an unborn baby. It is not known whether Lovenox passes into breast milk or if it could harm a nursing baby. Do not use Lovenox without telling your doctor if you are breast-feeding a baby. However, many doctors believe it is fine to breastfeed for the 6 weeks postpartum while still receiving Lovenox.

88 thoughts on “The MTHFR Tutorial – genetic mutation and cause of miscarriage

  1. Pingback: Recurrent Miscarriage happy ending | Tiny Heartbeats

  2. Thank you so much for this easy to read page on MTHFR. I was just diagnosed with A1298C (One A Copy – A1298C Heterozygous) after my second loss. They have me on a prescription prenatal, 1mg of folic acid and baby aspirin. They said I don’t need to start Lovenox before we get pregnant again but after reading your post I am concerned that I should be on something. Do you know if my form of MTHFR has the same issues as the others and puts me at risk of the same implications as the other forms?
    Thank you so much for sharing your knowledge.

  3. After 9 years of suffering from secondary infertility I am now almost 6 months pregnant with another baby boy. And I have Prophetess Asheika Stewart to thank!The whole process has it’s ups and downs as anyone having gone through it knows, but Prophetess Asheika Stewart prayed for me and my husband, and gave us her support and every step of the way, she recommended me her herbal pills.
    Prophetess Asheika Stewart did not give me false hope or empty promises and she definitely doesn’t sugar coat things. Instead she called me and give me advise and ask to know how I was feeling, she opened up to reassure me after a small scare, and she always called herself with pertinent news. Her service are warm and kind and understands the sensitivity behind this process. The only thing left to say is thank you, thank you, thank you…For making me a mother again and for giving my son the sibling he’s been longing for!

    you can always visit her on prophetessasheikastewart@yahoo.com

    Christine

  4. This is so helpful! Thank you! I was tested for MTHFR about 5 years ago because both of my parents have the mutation, though different types. I am C677T & A1298C Compound Heterozygous. My doctor tested my folate, B12, B6 and blood clotting and all was normal, so I never gave any more thought to it other than to take a multivitamin. Well, 4 years ago I got married, and we started trying to have children a little while later. Now, 2 years of trying, one miscarriage, two failed rounds of Clomid and two failed rounds of IUI later, I happened to come across a mention of MTHFR on a forum I was reading looking for encouragement about success stories after 2 failed IUI attempts. I googled and found your article. Thank you! I am going to call and talk to my fertility doctor immediately.

  5. I am so happy to find this page very informative. I have lost 8 babies throughout my life span, I use to loss it in the first trimester now as I got older I am loosing then in the second trimester. My last lost was a week ago at 13 and 4 days. Am on fertility treatments with the last 4 pregnancy. Now the problem is that the doctors are bit confused as to what is causing the problem. My water broke all the time and I always suffer from urinary tract infection and also have pcos.

    I do some underlying issues which they are taken care of, my problem is not getting pregnant, but is to keep it to full terms. Am always on predinsolne for NK along with progesterone, for mine is pretty low. I am now doing the research and thinking now that I may have mutation but I am going to be tested for it in the next couple weeks. Nothing was wrong with the foetus after I had the previous loss, now they are testing for any problems for this loss. I don’t have any live children and I am 43 but I never allow age to be a factor because my mom had me at at very late stage and so does my sisters, they have babies quite late.I have no health problem that runs in my family or does my husband, so it’s down to mutation testing as the last resorts. Am so happy I found this information.

  6. I just found out I have an MTHFR mutation — after 2 miscarriages. I was just put on Folgard but after reading ALL of these posts, I am scared to death to take it. What should I do??

    • You need to go on a vitamin that has active B12 and active folate..otherwise known as methylfolate. Thorne has a prenatal that has these ingredients. I would also take additional levels of methylfolate and methylcobalamin (B12) as well. I see a naturopath who has worked this out for me. It is hard to find one that knows about MTHFR, however there is a great clinic in DC that will do phone consulations that can help you as well.

    • i too was diagnosed with MTHFR (hetero). I was taking NeevoDHA, 3mg folic acid, and a BA and still ended up losing my last pregnancy 2 weeks ago (7 weeks, no heartbeat after seeing heartbeat the week before). So since this was my 3rd loss, I was sent to an RE and he ran a bunch of tests.. all normal. They are going to have me on lovenox with my next pregnancy to see if that helps me carry to term.

      • This is a very interesting discussions on the problems associated with the MTHFR mutations. Whilst is may be very hard to follow the chemistry I have a discussion on the chemistry on an associated site http://vitaminb12deficiency.net.au/ .
        What I would say is that the correct supplement (from the chemistry) is definitely the 5-methyltetrahydrofolate (5MTF) supplement. In addition, though you need to take an equally hihg level of methcobalamin (MeCbl), a particular analogue of vitamin B12. You should also get your levels checked, whihc can be reduced due to the deficiency

      • I also was taking NeevoDHA. I had a miscarriage last July and am terrified to get pregnant again.

    • I was on Folgard for two years before switching to a methylfolate supplement called NeevoDHA. I have a similar story to yours – two miscarriages and then the doctors started testing things. I found out that I had MTHFR (homozygous for the A mutation) over 4 years ago and still no further pregnancies. Talk to you your doctor about a prescription methyfolate supplement like Neevo; there are a few out there now and Thorne looks like it has a good product too. Unfortunately most doctors don’t know how to treat women with MTHFR so it’s good to find a fertility specialist that understands the mutation and some of them ‘seem’ to better understand the importance of using methylfolate and natural B-vitamins vs. folic acid and synthetic Bs. Unfortunately, the research out there is very narrow about the importance of methyfolate vs. folic acid and it takes a bit of time before most doctors will agree with something until there is enough scientific data to back up the claims (ie: vitamin D and probiotics use), which is completely understandable. A fertility doc can also test other blood clotting factors that can give you a better picture. In my case, I have been dx with many other issues such as endometriosis, thin endometrial lining, and PCOS. If you still have trouble getting pregnant after talking to fertility doctors and following what they recommend for MTHFR, please keep asking them to do further testing until they can figure out what’s going on or find another doctor that will listen! Doctors would keep telling me it would ‘happen’ and it hasn’t yet. Because of this hope, I put off a lot of testing over the years and it took me 12 years to find a doctor that dx me with endometriosis because of severe pelvic pain. Also, I think we get so wrapped up in our diagnoses that it starts to stress us out and it’s important to keep your stress levels as low as possible because stress is not good for your health or if you are trying to conceive – I know that is easier said than done of course! And remember, your partner could have some issues too and unfortunately fertility doctors don’t focus on the male infertility factor as much as they do for women, so it might be beneficial for your partner to talk to a urologist that specializes in male infertility as well – if things don’t seem to be getting anywhere in the conceiving camp. I am not a doctor and I do not wish to give you any medical advice of course, so it’s best to talk to someone that understand this genetic mutation and can give you a better picture on what to do. I hope my story provides you courage to keep an open dialogue with your doctors about this. I have gone through four fertility doctors before I found the right fit for me! Good luck to you in your path to being a mom!

      • Thanks Josalyn for your thoughtful reply. I challenged my RE on Folgard and while he agrees it has the synthetic folic acid, he specifically launched its use in Colorado. He said he had proven studies showing it works. So he said I’m free to take what I want, just make sure it mirrors the dosage in Folgard. I think I will take Folgard AND Thorne B-Complex and Thorne Pre-Natals.

  7. Hi a have a single mutation MTHFR (A1298C), and have had one very early miscarriage (no heartbeat) and a chemical pregnancy. My fertility specialist prescribes me Heparin//Lovenox and Folgard/Abtive Bio-B because of the mutation during IVF cycles.

  8. Firstly, thank you for a great blog, I found out recently that my husband and myself have this mutation. We were offered the dna testing after three consecutive 1st trimester miscarriages. I just wanted to give everyone some reassurance that it is possible to have a healthy child. My first pregnancy gave us a perfectly healthy child, we had a completely straight forward normal pregnancy, this is before we even knew about our gene mutation. I was only taking folic acid as far as prenatal supplements. I am now 17wks pregnant with our second child, we did not find out about our mutation till I was 12wks pregnant, so I wasn’t on any medication or taking any extra folic acid, just the standard prenatal multivitamin with dha. I’ve only just started taking extra folic acid now. So far our pregnancy is progressing well.

  9. Not folic acid we can’t convert it, that is the issue. Use methyl folate already active and ready to be absorbed. Very important point

  10. What a courageous group of women here, it is so hard to go through multiple miscarriages (my count is 6-all 1st trimester) and still have the faith and courage to try again. I just recently moved to northern Virginia and found a new dr and he tested for the mutation and I am positive for it and waiting to hear back from the hematologist to learn more details.
    I am also remarried and my new husband had a vasectomy before we got together so this having a baby journey just got more complicated. Oh and I have a bicornuate uterus too. I have very strong faith in God but sometimes I question the trajectory I am on. For why would God give me such a strong heart for children (I am a nanny) and yet the inability to carry one? And when do you give up and accept your childless fate? Sorry, to stand on my soapbox so long. Thank you, all of you, for your stories sometimes just knowing you aren’t alone in this struggle is invaluable.
    – Alisha

  11. Pingback: Blood, sweat and tears… | Broke-And-Barren

  12. please please please someone help me!!!
    i recently lost a baby 1st trimester went in for a rountine check two weeks after they told me my baby was fine a hb of 144.. i was so happy!! when i went in they said they could not find a hb long story short i had that big blood test done and it showed i had a gene mutaion deficiency- lack of folic acid they said i threw a blood clot in the emb cord and suffocated the baby i was devistated. My blood doc put me on folplex?? which i guess is similar to what these other ladys are on its b12 b6 and folic acid> its now been a year and we are still not preg? what can i do? i live in the florida area my ob was a very good doc was helping me fugure all this stuff out and died… i just need a good doc or someone with the same issues to maybe give me advice on anything i maybe can do to get preg again im so confused!! anyone?
    god bless Britt

    • Brittany, I am so very sorry for your loss. I think it’s really fortunate that you even found out you have that clotting problem. I have a couple of friends that have MTHFR and saw doctors in places like Houston, D.C. and Nashville. I can try to find phone #’s for you if you would like to call them for reference. I also belong to a Reproductive Immunology support group on Yahoo that I would recommend you connect with. You can find it here: http://health.groups.yahoo.com/group/immunologysupport/

      There are a ton of knowledgeable women in this group, and many of them know a great deal about this particular gene mutation, MTHFR. There are also Files you can search, and maybe find a doctor in your area.

      Don’t give up. You can find a way to get the help you need. I pray God gives you strength! I’m not sure if my site would help you at all, since that support group I mentioned has lots of info that I don’t, but for what it’s worth, here it is:

      http://reprorenegade.com/

      Best,
      Sara

    • Hey Britt,
      I’m sorry for your loss. I’m not trying to get pregnant nor have I ever experienced a miscarriage. But I do have a copy of this gene and found out because my borderline anemia wasn’t getting better when I was supplementing with B12 and folate. After finding out I had a copy of this gene my naturopath prescribed a methylated form of these vitamins (so they’re already in the active form). I’m from Florida, too, and there aren’t a lot of naturopathic doctors down there (I didn’t know what that even was until I moved out west, but it’s the best health care i’ve ever received). There’s an ND in Orlando that I hear great things about if that’s not too far for you. Here’s his site. http://www.drkalidas.com/ Good luck–

    • Hi Britt,

      I have not had a successful pregnancy yet and have been dx with homozygous MTHFR. I started taking NeevoDHA which has a high amount of active folate and B12, and also baby aspirin. My doctor thinks that the active folate is better than synthetic folic acid. My friend who also has MTHFR ended up having a successful pregnancy with Lovenox, NeevoDHA, and baby aspirin. Also, please make sure you push your doctor for answers – if they can’t figure out what’s going on, find another that will listen to you. After years of trying to have a successful pregnancy, I was also dx with endometriosis and a uterine septum – this was AFTER seeing 4 different fertility specialists. Unfortunately, I don’t know any doc in Florida. I know it is painful to lose a pregnancy…hang in there – it might take you a few tries to find a doctor that can figure out what’s going on – they are out there so please don’t give up hope!

    • Hey Brittany, what part of FL are you in? I am in Orlando and have a fantastic functional doctor that’s helping me. She doesn’t specialize in fertility, but we believe that once the whole body is balanced, then pregnancy can happen.

  13. This is one of the first really interesting blogs I have seen on MHTFR. I am in the Pittsburgh area and really looking for some help. I have not come across anyone that knows anything about MTHFR… and if they do they dismiss it. I am a compound heterozygote for C577/A1298. I have had 3 miscarriages and I also recently lost my baby girl at 23 1/2 weeks. I am broken, however the only thing that is helping me through is wanting to have another baby. However, I do not want to go throught this again. Any help would be very much appreciate.

    • Dear Michelle,

      I’m so very sorry for your loss. I know first-hand how difficult this can be. I lost my baby girl at 32 weeks. I too felt completely broken. In my experience with women TTC who know they have MTHFR, one of the biggest challenges is finding a care giver who is knowledgeable enough to guide them through. I have not personally had to cope with MTHFR and unfortunately I am at a loss for making a referral to a doctor who can specifically support you in that area. There is a previous post in this string in which a specific doctor is mentioned, and perhaps contacting that person would be a good place to start.

      Regarding support for your ongoing fertility journey, please call me (206-445-0553 or email me at julie@wholevisioncoaching.com) to set up an appointment to talk. We can explore how I can help you gain more peace and ease as you continue on your path to parenthood. Working with me, you can:
      – Regain a sense of control and clear understanding of what your choices are
      – Regain a sense of confidence in yourself, your body, and your choices
      – Reconnect with your friends and family and manage these relationships in a way that is comfortable and supportive of your needs
      – Heal any sense of failure, helplessness, or hopelessness
      … and more based on an assessment of your current experience and your desires

      I look forward to hearing from you.

      With love,
      Julie

      • Dear Sue,

        You are right to be cautious of information you find on the Internet and blogs of “authority” for sure. I recommend finding an N.D., M.D., geneticist, or endocrinologist who can talk with experience and expertise specifically about MTHFR before making decisions on a course of action. This is especially important when considering supplements or medications of any kind. Thank you for your comment.

        What is your personal experience? Are you trying to conceive now or have you in the past? Are you challenged by MTHFR? I hope to hear more from you.

        With love,
        Julie

      • this article is right-on ( after over 25 years of dealing with fibromyalgia, cfs I now have osteosporosis at 56 and a b12 deficiency which was crippling me – my cardiologist didn’t believe me till I found out about this missing gene!

    • Hi Michelle, I am so sorry that you have had to bear multiple miscarriages and the loss of your sweet baby. I have lost two babies ( but also have three healthy little ones) to anencephaly, a NTD which can be related to MTFHR which I also have. I know how frightening it can be to think about getting pregnant again after such a devestating loss. And yet it seems like the one thing that will help ease the pain.
      My doctor was also not really convinced about the MTHFR causing our problems, but I was able to get him to test me for the gene and prescribe Deplin when I brought in some notes after attending a seminar by Dr Neil Rawlinswhile i was in WA. He is an OB who has done extensive research on MTHFR (because he and his son have it.) His research is on the Kadlec Helath System website, or you can just google his name.His latest seminar is on youtube. his email is he is very kind and always responds quickly. he recommended that I take Deplin when trying to conceive and while pregnant–it is a medical food (methylfolate) that is prescribed for people with MTHFR (also prescribed for depression) and helps make up for the reduced metabolism of folic acid which people with this gene have. hope this helps.

      • Dear Cara,

        Thanks for your comments and response to Michelle. I hopeful the information you’ve shared here will be useful to many.

        With love,
        Julie

  14. I hope this story will give some of you hope. I had 1 miscarriage at 7 weeks and then delivered a perfectly healthy baby girl after carrying for 40 weeks. I have since had 3 more miscarriages, all around 7 weeks. I only recently found out that I have a homozygous mutation of MTHFR. My doctor has started me on a baby aspirin and 2 folgards daily. I had my daughter before I had begun treatment because I didn’t know of the mutation. There is hope for you! God Bless.

  15. Thanks for the very informative post.

    I have a question….
    We have had recurrent miscarriages – I am heterozygous for MTHFR, hubby is homozygous (can’t remember which positions). We have only just found this out. From a miscarriage point of view I know that embryos won’t survive if they inherit more than 2 variant genes (but they are not sure when the pregnancy loss occurs?). So for those embryos that have none, 1 or 2 variant genes is miscarriage related to the babies genetics or to blood clotting issues in the mother? And if that is the case if I am heterozygous and it is hubby that is homozygous should that mean we would be less likely to have problems than if I was the heterozygous one? ie does hubbies status have an impact on the likelihood of miscarriage?

    Thanks – it’s a very confusing topic!!
    Also it was only briefly mentioned that a good diet was essential but no other treatment suggested (for homozygous hubby I mean not for getting pregnant/baby etc), but on a brief skim through the posts looks like this could be a bit more serious? Should we be getting our daughter tested? parents?

    Thanks again,

    Clare

    • Dear Clare,

      I am not a doctor nor a gene specialist, and so I encourage you to take your questions to a doctor who is familiar with the fertility impacts of MTHFR. As a start, give a call to a fertility clinic in your area and ask if they might have a referral for such a specialist. Perhaps they may even have a doctor on staff who can provide some answers or resources.

      When you find a doctor in your local area who can answer your questions, please come back to us here and post the location and contact information. In this way, we can help each other find local resources. Finding a doctor familiar enough with MTFHR and it’s impacts on fertility is one of the most frequent requests I get. Unfortunately, I am often at a loss for a resource to refer to.

      I believe it would be very worthwhile to know one’s genetic status before attempting conception if there is a family history of MTHFR. For that reason, yes, you may want to get your daughter tested. Presumably, your parents are no longer trying to conceive and therefore knowing their genetic disposition would be academic.

      With love,
      Julie

      • Coach Julie,
        I am only leaving this comment here because I saw you mentioned you are “at a loss” for whom to refer to regarding MTHFR and fertility. I came across this site while doing research for my own site, which I just started. My site is called reprorenegade.com and I am chronicling my journey into reproductive immunology after losing 5 of 7 pregnancies. I am homozygous for MTHFR and I think it’s so essential that women find the right kind of fertility doctor, as you said. I went to see Dr. Jeffrey Braverman (New York) and he knows MTHFR and other issues extremely well. I listed resources on my site so other women can try to find the right avenue for help as well. I hope this is helpful, because I really do feel like I’ve come into an “aha” type of place after being told by other specialists that they couldn’t help me.

      • Dear Sara,

        Thanks for posting. I’m hopeful that the information you share on http://www.reprorenegade.com will be helpful. MTHFR is such a complex condition and finding a doctor who understands and has experience supporting women trying to conceive while managing the challenges of MTHFR is so important. Sharing our experiences and “ahas” is the most valuable kind of community — no matter our challenge, we are not alone. I’m glad you were able to persevere and find Dr. Braverman.

        With love,
        Julie

  16. Hi, I am 27 years old and have the 2 gene mutation. I successfully got pregnant after the first month of trying and carried the baby to term with no problems, until I delivered. The doctor had found a blood clot in my placenta and sent it off for testing. 6 weeks later I found out about the MTHFR. I took a prenatal vitamin and a baby asprin every day until 2 years later we decided to get pregnant again and again the first month we tried, we were pregnant. I started lovenox injections around 7 weeks with a regular prenatal vitamin and carried for 37 weeks. I did go through 2 amnios at the end to check for lung maturity but the baby was fine. It is now 2 years later and we decided to get pregnant again. I again got pregnant in the first month and am now on my lovenox injections again. I am 8 weeks now. My reason for writing this is you to know that while statistics show this and that, it is possible to have a healthy pregnancy so please do not give up hope!! I by no means am writing this to ‘brag’ I just want to let people know that God makes no mistakes and hang in there because he does have a plan for you!

    • Dear Ashley,

      Thank you for sharing your journey here with us. It can be a source of hope and encouragement for others who are struggling with MTHFR.

      With love,
      Julie

  17. I was recently diagnosed with having a double homocygous gene mutation. It explains my 3 miscarriages. I live in the Los Angeles California area. Do you know of any specialist that you can recommend? My current fertility Doctor has not been able to help.

    • Dear Martha,

      I don’t have a referral for the Los Angeles area at the moment, but I will send a shout out through my network and see what comes back. I’m sure you’re also working through your network. I know there’s a good match out there for you. Keep us posted here or contact me directly if you’d like to have a more intimate conversation.

      With love,
      Coach Julie

    • Hi Martha,

      Are you homozygous for the C677T or A1298C? North or South LA? I see a doctor in Westlake Village that is pretty good. Also, depending on what type of gene mutation you have, depends on how doctors will treat you or acknowledge that it could be an issue in miscarriage. I suffer from RPL as well and I have homozygous A1298C mutation. Unfortunately/fortunately, my experience is that they’ll treat you just the same way they treat all of the blood clotting disorders related to pregnancy and put you on Lovenox, Baby Asprin, and Folgard. I haven’t had any luck so far, but have not tried Lovenox. I currently take NeevoDHA, but it is due to my own research…not what my doctors prescribed initially; although a doctor must prescribe it. I am working with a naturopath that is ‘familiar’ with the issues, but not completely knowledgeable. I don’t know about other’s experiences, but I’ve noticed that most doctors don’t know about this mutation and don’t necessarily acknowledge that it’s even an issue. It’s good to find one that thinks outside of the box a little bit and from my experience just keep working until you do!

    • Please contact Dr. Stephen Rabin in Beverly Hills. 310-652-9347. I had the same condition and other doctors were not able to help. Dr. Rabin was absolutely wonderful and I have two beautiful children now. They are 6 years old and very healthy.

      • Dear KC,
        Thank you for the referral. I’m hopeful that Dr. Rabin will be able to help Martha as successfully as he did you.

        With love,
        Coach Julie

  18. I just wanted to say that it is very important NOT to take folic acid if you have MTHFR. People with MTHFR cannot convert it to methylfolate, and have a much higher risk of getting cancer if they take it. You have to take 5-MTHF. It is availlable by prescription (neevo prenatals), or through a company called THorne-http://www.thorne.com/Products/Neurological-Support/prd~B129.jsp

    • Maryann,
      Thank you for your comment about the folic acid. This is indeed an important point. Anyone considering adding any supplements should consult with their health team beforehand. Understanding the interactions of certain conditions and various supplements is vital to ensuring that good decisions are made to keep you on track for your best possible outcomes.

      In the case of trying to get pregnant and having MTHFR, the challenge is creating the opportunity to conceive a healthy baby and carry it to term. This does seem to carry with it a conflict of interests. Folic acid is important for the healthy development of a growing fetus. To make sure you are making the best decisions for your particular situation and health conditions in conjunction with the health of your baby, you must consult with appropriately licensed and certified health care professionals. Do not make these decisions on your own based solely on what you find on the Internet. Information here and on other blogs and info sites should provide you with a foundation from which to ask informed questions and broaden your understanding of your choices.

      With love,
      Coach Julie

      • Folic acid is not vital for the health of a growing fetus. Women with the MTHFR mutation have a very limited ability to metabolize synthetic folic acid. Active, already broken down L-methylfolate bypasses the MTHFR mutation and is 100% bioavailable for DNA synthesis and repair. It is a much better choice for folate regardless of your MTHFR status.

      • Dear Holly,

        Yes, perhaps “vital” is not the right word. Rather, as quoted from the March of Dimes, “Folic acid is a B vitamin that helps a baby’s neural tube to grow healthy during pregnancy. The neural tube will become a baby’s brain and spinal cord.” I consider that significantly important.

        Thank you for the clarification about the usefulness of the active, already broken down L-methylfolate. I know this will be helpful to many who are trying to conceive while contending with MTHFR, and it promises to be a good answer for everyone given it’s 100% bioavailability.

        To ensure the best decisions are made for a particular situation and health conditions in conjunction with the health of a growing baby, consulting with appropriately licensed and certified health care professionals is the best course of action. I know that when I was trying to conceive, I wanted to make sure I wasn’t missing anything. I didn’t want to have any blind spots around the interaction of various supplements and I also wanted avoid anything that could be contraindicated during pregnancy.

        With love,
        Coach Julie

  19. THANK YOU THANK YOU THANK YOU for this!!!

    I just found out I have this last week from my lab results. I have been thinking I was crazy for the last few years because I have had so many medical problems. I knew in my head that they had to all be related somehow because I just had way too many things going on (migraines, body pain, tiredness, forgetfulness, fibroids, and many more). This has been the most helpful and most understandable. Eevrything else I’ve read is just so confusing. I still need to go to a genetic counselor. I’m having my daughter testing now too and trying to get my family to see the seriousness in this and convince them to be tested.

    Thank you again!

    • Dear Kristen,
      I’m so glad you found this post so helpful for you and your family. It’s such a relief to know that someone out there understands and can help you further understand what you are experiencing. Sounds like you’ve been putting the pieces together for a while now and suddenly the picture snapped into place. I’m very glad of that.
      With love,
      Coach Julie

    • Dear An,
      Wonderful! It’s so great when the things click into a clear picture. When you have understanding, you can make better informed choices. I’m so glad you gained this clarity.
      With love,
      Coach Julie

  20. Check also you husbands. I have only one copy of C667T, but after 10 miscarriages, I found out that he has A1298C. Combined, they make a deadly combination. DO NOT USE FOLGARD! It is TOXIC to those with MTHFR mutations. I too was put on Folgard and baby aspirin and then lovenox shots! Babies died anyway. I do have 5 live children. Two have spina bifida occula, barely closed holes while taking FOLGARD. Our bodies CANNOT use man made folic acid. You need to supplement with Methylfolate, p5p or methylated B6 and Methylcobalamin (B12) Try Methyl Guard Plus 3 pills a day. Also I used nattokinase to prevent all fibrin build up in the body..no blood clots. I saved my children this way. go to http://www.mthfr.net.

    • Dear Tami,

      Your post corresponds very closely with Mayann’s. Thank you for sharing your experience with us. Yay and congratulations on finding a solution that helped to address your challenges as well as the needs of your womb babies.

      I would like to reiterate the following with emphasis for everyone reading this string:
      In the case of trying to get pregnant and having MTHFR, the challenge is creating the opportunity to conceive a healthy baby and carry it to term. This does seem to carry with it a conflict of interests. Folic acid is important for the healthy development of a growing fetus. To make sure you are making the best decisions for your particular situation and health conditions in conjunction with the health of your baby, you must consult with appropriately licensed and certified health care professionals. Do not make these decisions on your own based solely on what you find on the Internet. Information here and on other blogs and info sites should provide you with a foundation from which to ask informed questions and broaden your understanding of your choices.

      With love,
      Coach Julie

  21. Pingback: MTHFR Mutation and Me | Mother Rising

  22. I was just diagnosed with heterozygous C677T, after having two 1st trimester miscarriages. My doctor prescribed extra folic acid. I am assuming that because my homocysteine levels came back in the normal range that it is not affected and blood clots are not a concern for me. Still a scary diagnosis, but I am hoping that the extra folic acid is all I need for a healthy pregnancy.

  23. This is so confusing… I have had two early m/c and then was tested for MTHFR which I was diagnosed with C&A but my homosysteine levels were normal. I am currently 8 weeks pregnant again and my doctor has me on baby aspirin, but not on extra folic acid or B12 and B6. My doctor does not think that the MTHFR mutations had anything to do with my previous miscarriages but that “taking a baby aspirin a day won’t hurt me”. Is it possible that my doctor is not taking this seriously enough and I should go see a specialist? Thank you to anyone who can help. I am so sorry to all of you ladies who have experienced miscarriages. I just want the best chance for a healthy pregnancy.

    • Dear Jvoreis,

      I do believe it would be very worthwhile for you to seek out a doctor who specializes in fertility and who has experience working with patients who have MTHFR. You might want to look into researching NDs as well as MDs.

      Please let us know how you get on.

      With love,
      Coach Julie

  24. Hi there,

    We lost our son on June 27, 2011 at 24 weeks and 2 days. I had bleeding early in the first trimester that was said to be a SCH and then placenta issues. I suffered from PPROM (my water broke) at 14+5. I never had an infection, all issues stemmed from a poor placenta and blood clots in it. I have since been diagnosed with one copy of the c677t of MTHFR. I have a cousin who is the only person in our family that has been tested and she has both mutations. Our MFM does not want to put me on blood thinners for future pregnancies. I am taking 1mg of folic acid in addition to prenatal vitamins. What else do I need to do? Should I push our MFM to help me more with this?

    Thank you,

    Brooke

    • Dear Brooke,

      First, I want to offer you a sincere apology for such a delayed response. I’m hopeful that you have found satisfactory help and reliable information before now.

      I’m very sorry for the loss of your son last June. I can understand that this must have been terribly devastating for you. Thank you for sharing your story here. I know there are others who experience similar pain and loss and who will find comfort in knowing they are not alone.

      It’s great that you have discovered the genetics of the situation and can now make choices including that information into the mix. I suggest that you read through some of the comment posts in this string about folic acid and MTHFR. Take that information and information from other resources you may have and use it to formulate questions about what actions you should take to support a healthy pregnancy. Address these questions with your MFM. If you feel that you need more or are not getting satisfaction with the answers provided, find other health care professionals to consult with. Talk to and ask questions of as many fertility experts (medically licensed – NDs and MDs) who have experience specifically with MTHFR until you feel that you are as clear as you need to be to make confident decisions about the right choices for your situation.

      I hope you find this helpful. Please let us know how this journey continues for you.

      With love,
      Coach Julie

  25. Ummm… I think your chart might be backward.

    For C677T, a “T” allele is a problem, but a “C” is okay.

    For A1298C, a “C” is the problem allele, but “A” is okay.

    The first letter indicates the normal value at that location in the gene, and the last letter shows the mutated value.

    C677T homozygous = two T’s (or two A’s, that’s the same thing, just depends on the lab)

    A1298C homozygous= two C’s (or two G’s)

    • Dear JRB,

      Hmmm … perhaps. I am not a doctor and I am certainly not a gene specialist. I think what’s important here, however, is the usefulness of the conclusions about how MTHFR impacts trying to conceive and potential treatments. Anyone who has MTHFR should really be working closely with a health care professional who is well-versed in this genetic condition.

      Thank you for your comment, and I do appreciate your desire to keep the gene identification accurate.

      With love,
      Coach Julie

  26. Thank you for informing us about MTHFR. I have had two miscarriages in the past and my doctor recently left a message on my voicemail that said my tests showed I have two copies of a mutation – he did not say which ones. And said he wasn’t concerned because my homocystene levels were normal. He also said it probably wasn’t the cause of my two miscarriages. However, everywhere I research on the internet makes the MTHFR gene mutation issue seem really scary and pretty much no hope in sight in ever carrying a healthy baby. Plus, there is so much information on other “health” issues that this gene mutation can cause for you and the baby. Is my doctor oblivious to the seriousness related to this gene mutation? I would love to hear what other people have heard from their doctors so I can at least get some type of perspective on this and if it is even safe to try and conceive again. Thank you and I am so sorry for everyone here that has experienced a pregnancy loss. I understand what you are going through when the rest of the women who have never experienced something like this don’t have the slightest clue what it feels like.

    • I have mthfr c667t and have lost 10 babies, but kept 5. I wanted a big family. I first lost 3 in a row then went on progesterone suppositories 100 mg and kept 3 boys. I miscarried 2 more and then kept another boy. Then I found out about mthfr and went on folgard and baby aspirin and heparin 2 x a day and lost 3 more babies, all girls. Next they put me on lovenox once a day and lost my 9th baby, another girl. My next pregnancy I refused to do the shots because 4 babies in a row had died with the shots. So I researched on line any natural supplement that would reduce blood clots. I found Fibrovan.com and took 2 a day. I talked with the biochemist and he said it thinned the blood better than the shots. It has nattosyn in it. I also took folgard and baby aspirin. This time I delivered a healthy baby girl, but my last 2 children have spina bifida occula. Which means they have deep holes that barely closed ontheir spines, althou gh I took folgard. I lost my 10 baby after putting my supplements in my suitcase and not on my carry on and my luggage was lost for three days. I had heard the heart beat before we left and the baby died. Recently, I have been studying the mthfr more cloely and now the new research is not to take folgard or any normal folic acid as it is not active and the mutation doesnt allow my body to break it down and I store toxins. This makes sense because my two children still almost had spina bifida. Also, those with mthfr should continue taking methyfolate, active form of folic acid, for the rest of my life. Mthfr is found to cause depression. Fatigue, pain, thyroid issues, and many other major issues later in life. I had a pulmonary embolism after my 9th miscarriage after the d&c. Toxins cannot be released and store up in the body causing illness without the correct form of folic acid. I also still take natosyn. Interesting, I had my appendix taken out at 14 and so did my oldest son and he has mthfr. 98% of autistic children have mthfr. With mercury build up, and not taking the right folic acid, the toxins build up. Until I found out this informaion, I felt like I had cfs and depressed. Now im happy and have energy.

      • Dear Tami,

        I see that you made this entry earlier than your other. Thank you for sharing more details here. I think it’s helpful for a fuller understanding. I’m so glad you are feeling so much better. That’s wonderful!

        With love,
        Coach Julie

      • Tami I would love to be in contact with you as I have also have hetero c677t and after 3 healthy babies lost a baby girl at 17 weeks ( missed, passed around 13) and then a blighted ovum) Thanks! Sara Stuebs

    • I found out I have this mutation recently as well, after having 3 miscarriages. My infertility doctor doesn’t seem concerned as well! He told me to take 4mg of folic acid in addition to the prenatal vitamin and that’s it. I asked him if I should be taking aspirin or vitB6 and B12 but he said no. He is also suggesting starting me on Femara or Clomid, which doesn’t make sense to me at all since there’s nothing wrong with my ovulation. I really need to find another doctor.

      • Dear Nat,

        I’m very sorry that you have not had a reply to your post till now. Please forgive the delay. I am very hopeful that you’ve found some resolution to your challenges by now, and if not, I hope that what I write here will help to guide you in the right direction.

        Please, please, please find another doctor. I’m glad that you have a better understanding of your situation, and I encourage you to get support from a doctor who you can feel very comfortable with – someone you can feel a solid sense of trust and who takes the time to partner with you in making decisions about what action to take.

        Read through some of the comment posts in this string about folic acid and MTHFR. Take that information and information from other resources you may have, and then formulate questions about what actions you should take to support a healthy pregnancy. Address these questions with a doctor who you can really feel confident with. If you feel that you need more information or are not getting satisfaction with the answers provided, find other health care professionals to consult with. Talk to and ask questions of as many fertility experts (medically licensed – NDs and MDs) who have experience specifically with MTHFR until you feel that you are as clear as you need to be to make confident decisions about the right choices for your situation.

        I hope you find this helpful. Please let us know how this journey continues for you.

        With love,
        Coach Julie

  27. does anyone have any information with this without pregnancy. I am in my early 50s I had miscarraiges and a still born daughter. I am now realizing this gene mutation may have had a link to this. I have both types of MTHFR mutations and I developed celiac and just got so sick no energy and I am having b 12 shots and using 5-mthfr supplements I hear to take five mg a day and then other say 8mg. Anyone have any information on this in general for over all health. Please make sure you continue taking the folic and b 12 after you have your kids, and also watch for gluten issues. I have always always been very healthy and to loose my health so is awful. It is like having a horrible flu every day that weakness you feel. Just hope to get my health back, any help I would appreciate so much

  28. Just wanted to post that there is definitely hope. I am compound heterozygous for MTHFR. I found out after 2 miscarriages when I had to request testing because my MD said testing was normally only completed after 3 miscarriages. Luckily my mom told me to insist on testing and I listened. I did some research and found an MD who would let me do the heparin shots before I was pregnant. My previous MD wanted to wait until I was 6 weeks along and that could be too late. Long story short, I have a beautiful 13 month old baby boy by doing the following: folgard, baby asipirin, 2 shots of heparin daily from 1 month before to 6 weeks after prgenancy.
    Good luck to all of you! I know how hard miscarriage can be, but it is all worth it in the end.

  29. I have MTHFR just found out and have had 1 healthy baby girl in 97, I gave up for adoption and have had 4 misscarrages, thinking I gave my only baby up for adoption I have been very hurt deeeep down. Now I feel like im rejoycing because I had a dream about this very problem (MTHFR) and here I have it… God is amazing and works inn misteryous ways!!!

  30. Thank you very much for this information. On Feb. 16, 2004, I lost my first child (RIP Micah Chad)a mere 10 days from my due date. Blood tests were done and it turns out I have the homozygous MTHFR. My doc tried his best to explain it to me, but being grief stricken caused all that medical mumbo jumbo to go in one ear and out the other. All I knew was I had this disorder, and he had me scared to death thinking it would be SO incredibly difficult for me to ever have children, and that I would have to see a perinatologist instead of a regular OB. He said it was an absolute miracle that I carried my son as long as I did, since most women with this disorder miscarry within the 1st trimester.

    Fast forward three years: I found out in June of ’07 that I was pregnant again. I immediately went to the doc (a different one from my 1st) and was started on 81 mg aspirin, as well as shots of heparin twice a day. I was given ultrasounds once a month (which was awesome lol) and had my platelets checked every month as well. I never had to see a specialist! It was the polar opposite of what my 1st doc had told me!!

    So to all of you out there who are wondering if it’s possible to have more children…yes, with God, ANYTHING is possible. I was induced at 36 wks/5 days. One positive of this disorder: I don’t have to guess when my babies will come; I get to choose when lol.

    Mommies: Never give up hope.

  31. I had a miscarriage at 11 weeks in 2005. The baby had stopped growing around week 6. I became pregnant again in 2006 and had a wonderfully perfect baby girl at Christmas. During my pregnancy, I asked my OB to send me to a high risk Dr. for an in-depth ultrasound because I was 35. The high risk Dr. took blood samples and found that I have 1 gene for A. I never knew this until I went for my yearly exam just a couple of days ago. I started asking questions about having another baby and this came up. Nothing was done about it in my previous pregnancy, but the PA suggested that I begin taking folic acid, vitamin B, and a baby aspirin a day for the rest of my life. My question is, what kind of health problems can having 1 A gene cause? Should I be concerned about blood clots with another pregnancy since I had a c-section last time?

  32. Hi Ladies, My daughter had 4 miscarriages at 6 weeks,and recently had a stillborn @ 27 weeks. she also is has pcos and
    a bicorniate uterus. all the tests
    done on her and her little boy came back normal. she is on metformin for pcos, baby aspirin, and now the specialist started her
    on higher doses of folic acid and
    vitamin b6 and b12 anyone else
    been through anything like this, and now have a baby?? we are all
    so devastated. ts
    s

    • Yes, my wife is homozygous (not sure which), and has the factor V Leiden. She has had two pregnancies, though both came early. The oldest (6) was born at 37 weeks, and would not have made it full term as the placenta started to fall apart (unknown to the doctor until delivery). The twins (yes, twins) were born at ~35 weeks and are 3 years old now.

  33. This is a wonderful post and very informative. I have two copies of MTHFR and elevated protein s. After two miscarriages, I was diagnosed and I am pregnant again. I’m on heparin, baby aspirin, Zervalx (folic acid) and things look great so far!

  34. DO YOU HAVE ANY REPUTABLE RESOURCES FOR WHERE YOU ARE GETTING YOUR INFORMATION? I HAVE MTHFR TWO COPIES AND I AM HETERO FOR FVL. I HAVE BEEN TO THREE DOCS AND ONLY ONE THINKS I NEED TREATMENT (A FERTILITY DOC). I HAVE HAD THREE LOSES ONE BEING A 22 WEEK PLACENTA ABURPTION. I EMAILED THIS PAGE TO THE HEMOTOLOGIST THAT I AM SEEING WHO THINKS THIS IS NOT AN ISSUE BUT HE WAS ASKING FOR SOURCES SITED AND I COULDN’T TELL HIM. I AM GETTING SO CONFUSED. IS THIS A PROBLEM OR NO?

  35. I was just diagnosed with the MTHFR C677T single mutation. I am currently 6 weeks pregnant and scared to death now. I have had two miscarriages and I have a healthy 18 month old baby boy. I had my last mc in February and had my fertility Specialist run every test available to me. I am also “border line” on a blood cloting disorder as well. I am also taking the baby asprin daily. And now the Folgard. I meet with my dr on Tuesday. What are the risk percentages of birth defects? Can I have early testing done on the baby? Any info would be great. Thank you

    Casey

  36. Hi, I was diagnosed with this mutation about 2 wks ago, when I got my son’s autopsy back. My stillborn son was born febuary 6th. At 27 wks. I found out my babies heart was elarged, so my doc had me going to a high risk doc, And i had two amnio’s, one to see if they could find out something explaing his elarged heart which they found nothing, and anther at 36 wks. to see if his lungs were mature. Well my doc decided to induce me a wk. later, he thought having the baby born would be better then him being in the womb….so long story short, I went in to be induced and they found out he did not have a heart beat…So that’s my story. Before him I had two miscarriages, one at 9 wks. and one at 6 wks. What I am want ing to ask you, is if you have heard of alot of people with this mutation going on to have healthy children???I want to know if there is hope?Please write back…. Thanks, Ashley

    • I have compound mthfr. I lost two (11 weeks, 9 weeks)after having my first son.I was diagnosed after losing the second. I followed my regimen to the letter. My son was born preemie (for a different reason) but I was successful adding to my family. He is perfect in every way except his blood clots very quickly. I am still stressed and may be finished with the two wonderful boys I have.

    • I myself have MTHFR and have 4 healthy children but I’m not going to lie and say it was easy to have them I have suffered from a twin misscarriage two singleton misscarriages and my youngest child I lost her twin. My oldest son I had plecenta abropsion(SP?) he tried to come early twice. My oldest daughter was born at 27wks gestation I went into labor with her at 19wks gestation and spent that duraction in the hospital on complete bedrest they had me almost standing on my head the whole time. I found out I had FVL and MTHFR while I was pregnant with my third child and was put onto Lovenox and extra folic acid. I hope that helps you.

  37. I do thank you. Times have been really tough. You go through blaming yourself, which a part of me still feels that way. I have my heart break for my daughter. She is know 7 years old and was looking forward to her baby brother being here. The worst part is me as well as my sister-in-laws were all pregnant together, I can feel the hurt in my daughter when they come over with their babies. She does not say alot, but I tell her to talk about her brother as much as she wants.
    I was 33 1/2 weeks when he was born, he was stillborn. Just still going through all the what if’s. I don’t really know if my heart could ever be whole again. And I am absolutley terrfied of the day we might try again. I know I could not go through this again, my heart couldn’t take it. But on the other hand I want to eventually do want to try again. I am still just very lost. Thanks for listening.

    Vicki

  38. I still don’t really understand it all. My doctor told me I have MTHFR, I lost my son on 10-27-08 do to placenta abruption. All I was told was to take 3 folic acid pills a day, 400mcg. does this seem normal? Should my doctor have told me what kind I have?

    Thanks,
    Vicki Peeples

    • Hi Vicki,
      Apologies that its taken me a while to respond to your email! I have been a bit under the weather with sinus and cough…getting back into the swing of things now.

      I understand that it can be difficult to make sense of what happens to us especially when its so traumatic. I am so sorry to hear that you have experienced this. You pose a good question about the amount of folic acid you should be taking, I am not sure exactly what the amount is, I’m on 5 pills but I am not sure what the measurement is. Did they do more tests after the miscarriage to see if there was any other cause for the placenta abruption? How far along were you? Well, I am not an expert in the field of endocrinology so all I can really do is give you some emotional support, and direct you to some great resources – although I see you have read the MTHFR tutorial. I also have another genetic mutation with goes together with this and they prescribe a blood thinning drug Lovenox (it might be useful to enquire if this might be a contributor for you) during the pregnancy.

      Give yourself some time to grieve Vicki. It takes a little time to heal emotionally and physically from a miscarriage. Is it possible to give yourself a couple of months off the fertility treatments to recuperate? I know we often put pressure on ourselves because of the time issue, but it can be counter-productive if you just aren’t ready. Make sure you are taking good care of yourself, and giving yourself time to connect with yourself, whether its walking, meditation, gentle exercising. Its important that you give this gift to yourself. You deserve it.
      with love,
      Coach Louise

      PS Please consider Vicki, joining the telecircle group that is starting in a couple of weeks, I really believe it would be helpful to be part of a group of women (and myself) that will encourage and support you through this emotional journey.

  39. Thank you for sharing the information on MTHFR. I was dx with it over the summer … I have the ‘least troublesome’ type … which I guess is good … but it still stinks to have yet another dx on my chart.

    Also, thank you for reading my post and leaving such awesome comments of inspiration, hope, and kindness. You offer a perspective that is up-lifting and insightful. Thank you for taking the time to include me and my blog into your thoughts!

    Be well!
    Leigh

  40. Thank you for this post.
    My daughter has two C copies. She also had HELLP Syndrome with her first pregnancy. My grand daughter is considered a miracle baby.

    I have done my share of research on this gene mutation and found this article to be the best I’ve read so-far.

    Thank you for spreading the word.

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